Which can be used as purine analogues for a wide range of diagnostic and therapeutic applications.
2.
It is nonenzymatically cleaved to mercaptopurine, that acts as a purine analogue and an inhibitor of DNA synthesis.
3.
Azathioprine, also known by its brand name Imuran, is an immunosuppressive drug used in organ transplantation and autoimmune diseases and belongs to the chemical class of purine analogues.
4.
Although the purine analogue fludarabine was shown to give superior response rates to chlorambucil as primary therapy, no evidence shows early use of fludarabine improves overall survival, and some clinicians prefer to reserve fludarabine for relapsed disease.
5.
Many different treatments have been attempted, with limited success in certain patients : purine analogues ( pentostatin, fludarabine, cladribine ), chlorambucil, and various forms of combination chemotherapy ( cyclophosphamide, doxorubicin, vincristine, prednisone CHOP, cyclophosphamide, vincristine, prednisone [ COP ], vincristine, doxorubicin, prednisone, etoposide, cyclophosphamide, bleomycin VAPEC-B ).
6.
Gertrude Elion, working mostly with a group of fewer than 50 people on purine analogues, contributed to the discovery of the first anti-viral; the first immunosuppressant ( azathioprine ) that allowed human organ transplantation; the first drug to induce remission of childhood leukaemia; pivotal anti-cancer treatments; an anti-malarial; an anti-bacterial; and a treatment for gout.
7.
Many different treatments have been attempted, with limited success in certain patients : purine analogues ( pentostatin, fludarabine, cladribine ), chlorambucil, and various forms of combination chemotherapy regimens, including cyclophosphamide, doxorubicin, vincristine, prednisone ( CHOP ), cyclophosphamide, vincristine, prednisone ( COP ), and vincristine, doxorubicin, prednisone, etoposide, cyclophosphamide, bleomycin ( VAPEC-B ).
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